Christina Applegate, Jamie-Lynn Sigler and Edie Falco Lament the Loss of ‘Little Kid’ Years of Parenting: ‘It’s like a Death’ (Exclusive)

Edie Falco says she sometimes regrets the end of her time as a parent of young children.

“No one talks about it when those little kids go missing — it’s like death,” said Falco, 60, whose son Anderson is 19 and daughter Macy is 16.

Falco trades parenting stories and more with her The Sopranos star Jamie-Lynn Sigler, in the second episode of MeSsy, Sigler’s new podcast with Christina Applegate, PEOPLE has an exclusive preview of the podcast episode before it airs March 26.

MeSsy podcast promo art

The second episode of Applegate and Sigler’s MeSsy podcast is out March 26.

Production of wires

Christina Applegate and Jamie-Lynn Sigler photographed exclusively by John Russo in the Hollywood Hills on March 6, 2024.

Jamie-Lynn Sigler and Christina Applegate, photographed for PEOPLE on March 6, 2024.

John Russo

How Christina Applegate & Jamie-Lynn Sigler ‘Help Each Other Through’ MS: ‘We Both Needed This’ (Exclusive)

Sigler, 42, whose two boys, Jack and Beau, are 5 and 10, is still navigating her younger years, but says on the podcast that she’s “holding on to all the little baby things,” like the fact that her son Jack just lost his first teeth and that his hand “still has no joints”.

Jamie-Lynn Sigler

Jamie-Lynn Sigler, husband Cutter Dykstra and sons Jack and Beau.

Courtesy of Jamie-Lynn Sigler

Applegate, whose daughter Sadie is 13, adds: “It drives me crazy that we’re not going to get it back.”

Falco says he cherishes the memories of those early days. “Early parenthood is crazy, but it’s some of the most divine, precious hours of my life,” the Nurse Jackie star says on the podcast. “When they both fall asleep on top of you while you’re watching TV and it’s quiet and you realize, ‘Oh my God, I didn’t know I could feel this love.’ And then they’re just gone forever and all that’s left are memories and they’re all over your iPhone!”

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Edie Falco with son Anderson Falco and daughter Macy Falco

Edie Falco with her son Anderson and daughter Macy in 2011.

Amanda Schwab/Startraksphoto.com/Instar

Applegate, who admitted that living with multiple sclerosis has changed the way she can parent, jokes that she wants to keep her daughter as close as possible for as long as possible: “I told Sadie when she goes to college, wherever that is, I’m going to move in with her. I highly encourage Los Angeles universities. I wonder, ‘Why would you live in a dorm when we have our own nice house?’ I’m doing everything I can to make her stay here.”

Christina Applegate, left, and Sadie Grace LeNoble at the 75th Annual Emmy Awards on Monday, Jan. 15, 2024, at the Peacock Theater in Los Angeles.

Christina Applegate and daughter Sadie at the Emmy Awards in January 2024.

Jordan Strauss/Invision for the Television Academy/AP Images

Christina Applegate Says Having MS Has Changed Her As A Parent: ‘It’s Heartbreaking’ To Say ‘I Can’t’ (Exclusive)

Applegate and SIgler started the podcast, which debuted on March 19, after their mutual friend Lance Bass encouraged them to connect over their shared MS diagnoses. “We would talk on the phone for hours, laughing and crying,” the Dead to Me star told PEOPLE of her friendship with Sigler. “And then we said, ‘This helps us. Let’s film this.'”

Christina Applegate and Jamie-Lynn Sigler photographed exclusively by John Russo in the Hollywood Hills on March 6, 2024.

Applegate and Sigler photographed for PEOPLE March 2024.

John Russo

MeSsy chronicles their journeys with MS, but it’s not just about MS — “That would be boring,” jokes Applegate. The podcast also features friends and colleagues like Martin Short and Falco, who admitted to Sigler that she felt “intimidated” by her on set The Soprano familydespite the fact that Sigler was still a teenager when she started the series.

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“You came across as so confident,” Falco told Sigler. “And the truth is when I was a kid in high school I was a weirdo and when I met girls like you I was terrified of them. They just looked like they knew what was going on and how to be with people. to be honest with you, you scared me me. That’s true.”

Sigler was touched by the recognition: “It’s wild for me because I was such a little mess inside. I felt undeserved every moment I was there.”

The two also bonded over the fact that they both battled health issues while filming The Soprano family. Sigler hid the fact that she had been diagnosed with MS, while Falco was quietly being treated for breast cancer. But in both cases, Sigler says, their co-star James Gandolfini knew something was wrong — and both confided in him.

THE SOPRANS, Jamie Lynn Sigler, James Gandolfini, Edie Falco, Robert Iler, 'Pax Soprana'

Jamie-Lynn Sigler, James Gandolfini, Edie Falco and Robert Iler on the set of The Sopranos in 1999.

HBO/Courtesy of the Everett Collection

“They called acting coaches to the set for me because I couldn’t tell anyone what was wrong, but people could tell something was wrong,” Sigler said. Falcu said, “I’m so sorry when you were going through breast cancer, and that a lot of it was quiet. You said Jim called you out and said something was up. He did the same thing to me. He pulled me one day. aside and said: ‘Something is wrong and you are not telling anyone’, and at that moment I told him.”

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